About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

We are looking for a motivated candidate to support late-stage process development of Antibody-Drug-Conjugates (ADCs) and other emerging conjugation modalities. Primarily, the candidate will independently design and perform conjugation experiments, perform downstream operations such as Tangential Flow Filtration (TFF) purifications, and analyze experimental and analytical results either running analyses independently or via sample submission toAnalytical Developmentcolleagues. Thislate-stagedevelopment work willultimately supportprocess characterization, commercialization,and regulatory submissions for ADC therapies in AbbVies development pipeline.Thecandidate is expected to work with managers and key stakeholders or collaborators to effectively plan and communicate experimental timelines and results.ADC development work is inherently interdisciplinary and cross-functional, so a strong candidate will be able to quickly learn and developfunctional knowledgeof adjacent development areasto understand how thoseinterface withconjugation process development.

Responsibilities

• Maintain a high degree of productivity inlabto support conjugation process development: independently design, execute, and interpret key experiments to answer scientific questions.
• Perform conjugation and purification operations at reaction scales ranging from ~mL scale reactions up to a 10L reactor.
• Perform routine sample preparation and operation of HPLC-based analytical assays.
• Understand scale dependence of chemical reactions or purifications, or engineering scale factors.
• Document and share results via electronic laboratory notebooks, internal technical presentations,andtechnical reports.
• Learn, understand, and master relevant laboratory techniques, and serve as a subject matter expert and mentor for junior scientists inlab.
• The candidate will understand and adhere to corporate standardsregardingcode of conduct,safetyand GXP compliance.
• Work collaboratively within a multi-disciplinary team, including analytical chemists, process chemists, and manufacturing personnel.

• BS with 10+ years', MS with 8+ years', and PhD with 0+ years' industry experience.
• Degreein chemistryor chemical engineering.
• Strong scientific communication and interpersonal skillsto drivecollaboration within the conjugation process development team and withcross-functional partners.
• Thoroughunderstanding oforganic chemistry,theoreticalconceptualization of reaction mechanisms,andpracticalfluencywithwet-lab operationsand running chemical reactions.
• Extremely knowledgeablein HPLC/UPLCinstruments: familiar with equipment care and maintenance best practicesfor shared lab equipment,ability to perform basic troubleshootingof HPLC systems.
• Ability tomultitask and meettimelines.

PreferredQualifications

• Prior experience with drug-conjugate chemistry orconjugation process development is not necessary but strongly preferred.
• Advanced degree (MS or PhD) inorganic chemistry, orexperiencein small molecule chemistry.
• Experience in design-of-experiments (DoE), quality-by-design (QbD), and development of statistical and mathematical models

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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https://www.abbvie.com/join-us/reasonable-accommodations.html