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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Postdoctoral Scholar, Cell Therapy to be in Cambridge, MA.

Purpose:

This postdoctoral position will focus on developing optimized flow virometry techniques and workflows for therapeutic tLVVs with the goal of developing reproducible single-particle measurements and understanding whether these measurements predict tropism, functional potency, and safety in preclinical models.   

In this position, the Postdoctoral Scholar, Advanced Flow Virometry, will develop and apply flow virometry methods to characterize targeted lentiviral vector quality attributes for in vivo applications. The role focuses on generating reproducible single-particle measurements, comparing flow virometry with established analytical methods, linking particle phenotypes to transduction, potency, and safety outcomes, and building cross-functional scientific insight that supports analytical and process development in cell and gene therapy.  The scholar will interpret complex data sets, collaborate extensively with complementary internal teams, and communicate findings in scientific and cross-functional forums. 

You will be responsible for:

• Design, optimize, and execute advanced flow virometry workflows to characterize targeted lentiviral vector particle heterogeneity, envelope integrity, aggregation, and contaminant extracellular vesicles at the single-particle level.

• Perform comparative analytical studies against established methods such as Western blot, DLS, SEC-MALS, ELISA, and density gradient approaches, and generate validation data sets that assess agreement, specificity, and reproducibility of flow virometry measurements.

• Correlate particle phenotypes with functional outcomes, develop statistical models linking analytical measurements to transduction and potency, and communicate results through group meetings, cross-functional forums, internal scientific showcases, and external scientific conferences as appropriate.

• Development, training, conferences, internal meetings, and symposia

Qualifications:

• PhD in Virology, gene therapy, flow cytometry/flow virometry, analytical development relevant to role, bioengineering, biotechnology, or related discipline with 0-1 years of experience is required.

• Expertise in virology, analytical characterization, bioengineering, cell biology, biotechnology, or a related scientific discipline relevant to viral vectors and single-particle analysis 

• Position will require generation, use, and testing of lentivirus particles.  Applicants should be comfortable working in BSL2+ laboratory conditions 

• Demonstrated ability to design experiments, analyze complex data, and compare emerging analytical methods with established assays using scientifically rigorous approaches. 

• Ability to work effectively across cross-functional teams and communicate scientific concepts and results clearly to technical and non-technical audiences. 

• Experience with statistical interpretation, correlation analyses, and data-driven problem solving in a research environment. 

• Strong written and verbal communication skills, with the ability to present findings in internal meetings, scientific forums, and conference settings. 

• 5% travel expected

Preferred Knowledge, Skills and Abilities:  

• Experience with flow cytometry is highly preferred 

• Experience with enveloped viruses, enveloped viral vectors, or related, relevant modality preferred 

• Experience with single-particle characterization methods, lentiviral vector biology, or assay validation a plus. 

• Model-building experience helpful 

• Experience in gene therapy, viral vector analytics, virology, or biopharmaceutical analytical method development welcome but not required.

  

 Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

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The anticipated base pay range for this position is :

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